"We are open to a wide spectrum of collaboration with academic partners as well as with partners from applied research, industry and agronomy."
- Antiproliferative and toxicity tests using various cultures of immortalized cells
- Tests of hepatotoxicity of drugs and other xenobiotics
- Preparation and incubation of precision-cut liver and intestinal slices
- Isolation and cultivation of primary cultures of hepatocytes
- Preparation of subcellular fractions (animal and human organs, parasites, plants, cell cultures)
- Assays of enzyme expression and enzymatic activities
- Identification of metabolites of drugs and other xenobiotics
- In vivo animal studies
- Isolation of helminths from infected hosts
- Ex vivo cultivations of helminths
- Coprological testing
- Drug biotransformation and transport studies in humans, animals, parasitic helminths and plants
- Effect of drugs, dietary supplements, natural compounds and other xenobiotics on expression and activity of drug-metabolizing enzymes
- Pharmacodynamics mechanisms of drug resistance in helminths
- Identification of metabolites of drugs and other xenobiotics in humans, animals, parasitic helminths and plants
- Toxicity and interactions of natural substances/ food supplements with drugs
- Mechanisms of drug resistance in parasitic helm inths
- Accredited vivarium
- Cell and tissue laboratory
- Laboratory for isolation and cultivation of helminths
- Laboratory for molecular biology (electrophoresis, Western blotting, qPCR)
- Analytical devices (spectrophotometers, spectrofl uorimeters, HPLC, LC/MS)
Publications in respected international journals.
"Our mission is to get better knowledge of fate of drugs in various organisms and the factors that could affect drug efficacy and safety.“
- 18-08452S “Anthelmintics in plants – interactions with polyphenols biosynthesis and antioxidant defence”
- 18-07724S “Circulation of anthelmintics in environment – does it contribute to drug resistance development in helminths?“
- 18-09946S “Metabolism of terpenes and mechanisms of their toxic effects in human liver“
- 18-07281Y “In vitro and ex vivo models to study drug-drug interactions of antiviral drugs on intestinal transporters“
- 17-11954Y “UDP-glycosyltransferases in Haemonchus contortus – players in drug-resistance?”
- No. P303/12/G163 “Centre of drug – dietary supplement interactions and nutrigenetics”
- UNCE18/SCI/012 “Centre of research of hosts-parasites interactions“
- PRIMUS/17/SCI/4 “Úloha mikroRNA v lékové rezistenci hlístic”
Please contact CPPT UK
Web: www.cppt.cuni.cz/
Mail: transfer@cuni.cz
Tel.: +420 224 491 255
Prof. Ing. Barbora Szotáková, Ph.D.
Department of Biochemical Sciences
Web: http://portal.faf.cuni.cz/Groups/Drug-resistance-and-drug-interactions
Centrum pro přenos poznatků a technologií, Univerzita Karlova
Web: www.cppt.cuni.cz/
Mail:
Tel.: +420 224 491 255
Adresa kanceláře:
Petrská 1180/3
110 00 Praha 1
Korespondenční adresa:
Ovocný trh 560/5
116 36 Praha 1
