Formulation and Evaluation of Solid and Liquid Dosage Forms

„Our research team is concerned with the formulation, development and evaluation of solid and liquid dosage forms.“


- Formulation of solid and liquid dosage forms

- Evaluation of tablets using pharmacopoeial methods (disintegration time, tensile strength, friability, porosity, dissolution test)

- Flowability testing of particulate material (flow rate, angle of repose, bulk and tapped density, porosity, sieve analysis, microscopy)

- Evaluation of compressibility of tableting materials using the parameters of compaction equations, energy profile of compression, parameters of the stress relaxation test and the tablet crushing kinetic

- Evaluation of liquid dosage forms (density, viscosity, osmolality, surface tension)

We are open to a wide spectrum of collaboration with academic partners as well as with partners from the industry.


- Formulation and evaluation of solid dosage forms, especially tablets and powders

- Formulation and evaluation of liquid dosage forms, especially oral, ophthalmic and parenteral dosage forms

- The study of the current and new excipients for solid and liquid dosage forms

- Testing of dissolution profile of API from dosage forms including nano- and microfi bres using USP 4 Flow-Through Cell method and methods of Ph. Eur

Key Research Equipment

Study of Material Properties

- Fluorescence imaging system (Olympus BX51)

- Moisture analyser (Precisa Instruments AG)

- Granulate & powder flow tester (Erweka GT)

- Bulk density meter (Copley Scientific Scott Volumeter)

- Tapped density tester (Erweka SVM 102)

- Vibratory sieve shaker (Retsch AS 200 basic)

- Differential Scanning Calorimeter (Netzsch DSC 200 F3 Maia)

- Atomic force microscope (NanoSurf easyScan2 Flex AFM)

- Scanning tunneling microscope (NanoSurf easyScan2 STM)

- Zeta potential analyzer (Mavern Zetasizer Nano ZS)

- MASTERSIZER 3000 with AeroS for dry mode and Hydro MV for wet mode (Malvern)

- Force tensiometer (Krüss K100)

- Rotational rheometer (Malvern Kinexus)

- Viscometer (Brookfield DV-E)

- AccuPyc (Micromeritics)

Powder and Granule Preparation

- Zeta potential analyzer (Mavern Zetasizer Nano ZS)

- Force tensiometer (Krüss K100)

- Rotational rheometer (Malvern Kinexus pro)

- Viscometer (Brookfield DV-E)

- Fluid bed dryer/granulator (Glatt Uniglatt)

- All-purpose-equipment – motor drive (Erweka AR 401)

- Wet granulator (Erweka FGS)

- Stainless steel cube mixer (Erweka KB 15S)

- Turbula T2F (WAB)

- Planetary mill PM 100 (Retsch)

Preparation and Testing of Tablets

- Compression tool (Adamus HT)

- Material testing machine (Zwick/Roell T1-FRO 50)

- EP-1 single punch tablet press with compression force (Erweka)

- Digimatic indicator (Mitutoyo Absolute ID-S1012B)

- Tablet hardness tester (Dr. Schleuniger Pharmatron 8M)

- Tablet disintegration tester (Erweka ZT 301)

- Tablet friability tester (Sotax FT2)

- Calorimetric thermometer (Parr 6772)

- Dissolution system for USP apparatus 1, 2, 5 and 6 (Sotax AT7 Smart)

- Dissolution system for USP apparatus 4 (Sotax CE-1)

- UV/VIS spectrophotometer (Anayltik Jena Specord 205)

- HPLC (Agilent 1200)

- Stability testing chamber

Liquid Dosage Forms

- Laboratory Density Meter DMA 4100 (Anton Paar)

- Semi-micro-osmometer DL (Knauer)

Partnerships & Collaborations

Main Projects

- Project No. 1286218/2018 of Grant Agency of Charles University. TRPĚLKOVÁ, Ž., ONDREJČEK, P., ŠKLUBALOVÁ, Z., et al: Study of fractal aspects of flow and consolidation behaviour of pharmaceutical excipients as prospective carriers for interactive mixtures with drugs. 2018–2020.

- Project No. 322315/2015 of Grant Agency of Charles University. HURYCHOVÁ, H., ŠKLUBALOVÁ, Z., et al: The study of fractal aspects of flowability of particulate matter in pharmaceutical technology. 2015–2018

- Project Technological Agency TAČR TA01010128: MOŠA, M., ŘEHULA, M., JABO, A., ŠKLUBALOVÁ, Z. Development of freeze-dried tablets for alergen vaccines. TAČR 2011–2015


- University of Applied Sciences Northwest, Institute of Pharma Technology, Switzerland

- University Bonn

- Martin-Luther Universität Halle-Wittenberg

- Faculty of Pharmacy VFU, Dept. of Pharmaceutics, Brno

- Zentiva, k.s., Praha

- Teva Pharmaceuticals, Opava

- Dr. Müller Pharma, s.r.o.

- VAKOS XT a.s., Praha

- mcePharma Bílovec

- SYNPO a. s., Pardubice

- Contipro, a.s., Dolní Dobrouč

- University of Pardubice, Faculty of Chemical Technology

- University of Chemistry and Technology, Prague

- Brno University of Technology, Faculty of Chemistry

- Ardeapharma, a. s., Ševětín

- Hospital pharmacy (FN Motol, Všeobecná FN, FN Královské Vinohrady)

- Masaryk University, Faculty of Science, Brno


Publications in respected international journals, research reports.

Are you interested in this expertise?

Please contact CPPT UK



Phone: +420 224 491 255

Experts and their Department

Assoc. Prof. PharmDr. Zdeňka Šklubalová, Ph.D.

Department of Pharmaceutical Technology


Poslední změna: 11. říjen 2019 18:40 
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