Formulation and Evaluation of Solid and Liquid Dosage Forms ****************************************************************************************** * ****************************************************************************************** „Our research team is concerned with the formulation, development and evaluation of solid forms.“ ****************************************************************************************** * Offer ****************************************************************************************** - Formulation of solid and liquid dosage forms - Evaluation of tablets using pharmacopoeial methods (disintegration time, tensile strengt porosity, dissolution test) - Flowability testing of particulate material (flow rate, angle of repose, bulk and tapped porosity, sieve analysis, microscopy) - Evaluation of compressibility of tableting materials using the parameters of compaction profile of compression, parameters of the stress relaxation test and the tablet crushing k - Evaluation of liquid dosage forms (density, viscosity, osmolality, surface tension) We are open to a wide spectrum of collaboration with academic partners as well as with par industry. ****************************************************************************************** * Expertise ****************************************************************************************** - Formulation and evaluation of solid dosage forms, especially tablets and powders - Formulation and evaluation of liquid dosage forms, especially oral, ophthalmic and paren forms - The study of the current and new excipients for solid and liquid dosage forms - Testing of dissolution profile of API from dosage forms including nano- and microfi bres Flow-Through Cell method and methods of Ph. Eur ****************************************************************************************** * Key Research Equipment ****************************************************************************************** *========================================================================================= * Study of Material Properties *========================================================================================= - Fluorescence imaging system (Olympus BX51) - Moisture analyser (Precisa Instruments AG) - Granulate & powder flow tester (Erweka GT) - Bulk density meter (Copley Scientific Scott Volumeter) - Tapped density tester (Erweka SVM 102) - Vibratory sieve shaker (Retsch AS 200 basic) - Differential Scanning Calorimeter (Netzsch DSC 200 F3 Maia) - Atomic force microscope (NanoSurf easyScan2 Flex AFM) - Scanning tunneling microscope (NanoSurf easyScan2 STM) - Zeta potential analyzer (Mavern Zetasizer Nano ZS) - MASTERSIZER 3000 with AeroS for dry mode and Hydro MV for wet mode (Malvern) - Force tensiometer (Krüss K100) - Rotational rheometer (Malvern Kinexus) - Viscometer (Brookfield DV-E) - AccuPyc (Micromeritics) *========================================================================================= * Powder and Granule Preparation *========================================================================================= - Zeta potential analyzer (Mavern Zetasizer Nano ZS) - Force tensiometer (Krüss K100) - Rotational rheometer (Malvern Kinexus pro) - Viscometer (Brookfield DV-E) - Fluid bed dryer/granulator (Glatt Uniglatt) - All-purpose-equipment – motor drive (Erweka AR 401) - Wet granulator (Erweka FGS) - Stainless steel cube mixer (Erweka KB 15S) - Turbula T2F (WAB) - Planetary mill PM 100 (Retsch) *========================================================================================= * Preparation and Testing of Tablets *========================================================================================= - Compression tool (Adamus HT) - Material testing machine (Zwick/Roell T1-FRO 50) - EP-1 single punch tablet press with compression force (Erweka) - Digimatic indicator (Mitutoyo Absolute ID-S1012B) - Tablet hardness tester (Dr. Schleuniger Pharmatron 8M) - Tablet disintegration tester (Erweka ZT 301) - Tablet friability tester (Sotax FT2) - Calorimetric thermometer (Parr 6772) - Dissolution system for USP apparatus 1, 2, 5 and 6 (Sotax AT7 Smart) - Dissolution system for USP apparatus 4 (Sotax CE-1) - UV/VIS spectrophotometer (Anayltik Jena Specord 205) - HPLC (Agilent 1200) - Stability testing chamber *========================================================================================= * Liquid Dosage Forms *========================================================================================= - Laboratory Density Meter DMA 4100 (Anton Paar) - Semi-micro-osmometer DL (Knauer) ****************************************************************************************** * Partnerships & Collaborations ****************************************************************************************** *========================================================================================= * Main Projects *========================================================================================= - Project No. 1286218/2018 of Grant Agency of Charles University. TRPĚLKOVÁ, Ž., ONDREJČEK Z., et al: Study of fractal aspects of flow and consolidation behaviour of pharmaceutical prospective carriers for interactive mixtures with drugs. 2018–2020. - Project No. 322315/2015 of Grant Agency of Charles University. HURYCHOVÁ, H., ŠKLUBALOVÁ study of fractal aspects of flowability of particulate matter in pharmaceutical technology - Project Technological Agency TAČR TA01010128: MOŠA, M., ŘEHULA, M., JABO, A., ŠKLUBALOVÁ of freeze-dried tablets for alergen vaccines. TAČR 2011–2015 *========================================================================================= * Collaborations *========================================================================================= - University of Applied Sciences Northwest, Institute of Pharma Technology, Switzerland - University Bonn - Martin-Luther Universität Halle-Wittenberg - Faculty of Pharmacy VFU, Dept. of Pharmaceutics, Brno - Zentiva, k.s., Praha - Teva Pharmaceuticals, Opava - Dr. Müller Pharma, s.r.o. - VAKOS XT a.s., Praha - mcePharma Bílovec - SYNPO a. s., Pardubice - Contipro, a.s., Dolní Dobrouč - University of Pardubice, Faculty of Chemical Technology - University of Chemistry and Technology, Prague - Brno University of Technology, Faculty of Chemistry - Ardeapharma, a. s., Ševětín - Hospital pharmacy (FN Motol, Všeobecná FN, FN Královské Vinohrady) - Masaryk University, Faculty of Science, Brno ****************************************************************************************** * Achievements ****************************************************************************************** Publications in respected international journals, research reports. ****************************************************************************************** * Are you interested in this expertise? ****************************************************************************************** Please contact CPPT UK Web: www.cppt.cuni.cz/ [ URL "https://cppt.cuni.cz/"] Mail: transfer@cuni.cz Phone: +420 224 491 255 ****************************************************************************************** * Experts and their Department ****************************************************************************************** Assoc. Prof. PharmDr. Zdeňka Šklubalová, Ph.D. Department of Pharmaceutical Technology Web: https://portal.faf.cuni.cz/Groups/Drug-Delivery-Dosage-Form-Technology/ [ URL "https: portal.faf.cuni.cz/Groups/Drug-Delivery-Dosage-Form-Technology/"]