Laboratory of Immunoregulation

"We are looking for collaboration with academic partners as well as public and private organisations in the fields of regulation of immune response and regenerative medicine."


- Expertise within a diverse range of issues related to molecular and cellular immunology

- Experience with animal models and cell transplantation

- Analysis of the impact of specific drugs or new materials on immune system

- Highly qualified, skilful, intelligent and enthusiastic blondes

Know-how & Technologies

The aim of our research is to characterise the molecular and cellular mechanisms of specific immunity which can be consequently applied in targeted immunoregulation for both the experimental work and the clinical practice.

- Skin and corneal transplantation in laboratory animals and in vivo immunoregulation

- Study of cooperation among cells of the immune system in tissue cultures

- Regulation of gene expression, characterization of the functions of signalling molecules

- Study of stem cells and their use in regenerative medicine

Content of Research

- Study of cellular and molecular mechanisms specific to transplantation immunity

- The specific modulation of immune responses with the aim of applying apply acquired knowledge in clinical practice

- The use of nanofi ber scaffolds as cell or drug carriers in in vitro or in vivo experimental systems

- Investigation of the therapeutic effect of mesenchymal stem cells in experimental mouse models; study of interaction of mesenchymal stem cells with specific drugs

Main Capabilities

- Cell cultures

- Isolation and differentiation of stem cells

- Functional immunological testing in vivo and in vitro

- Standard immunology and cell biology assays (FACS, cytokine detection, proliferation assays)

Key Research Equipment

- Cell and tissue culture laboratory

- Flow cytometry facility (LSRII, MACS sorter etc.)

- Standard equipment for immunology and cell biology assays (ELISA, WST, NO detection, proliferation assays)

- Equipped laboratory for histochemistry and immunohistochemistry

- Microscopic facility

- Equipped laboratory for immunogenetics (cyclers, real-time PCR instruments)


Publications in respected international journals with high impact factors:

- Journal of Immunology

- Journal of Controlled Release

- Immunology

- Transplantation

- Journal of Tissue Engineering and Regenerative Medicine

- Stem cells and Development

- Cell Transplantation

- Investigative Ophthalmology & Visual Science

Partners and Collaborations

Academic Partners

Cooperation with many academic research groups in the Czech Republic as well as in Europe: Laboratory of the Biology and Pathology of the Eye, Institute of Inherited Metabolic Disorders, First Faculty of Medicine, Charles University in Prague and General University Hospital (Prague, Czech Republic) | Institute for Clinical and Experimental Medicine (Prague, Czech Republic) | Department of Transplantation Immunology, Institute of Experimental Medicine, Czech Academy of Science (Prague, Czech Republic)

Private and Public Sector

European Eye Clinic Lexum

Main Projects

- P304-11-0653 Targeted Differentiation and Transdifferentiation of Limbal and Mesenchymal Stem Cells and Their Therapeutic Use in Preclinical Models (Grant Agency of the Czech Republic)

- 14-12580S Treatment of Severe Ocular Surface Injuries Using Limbal and Mesenchymal Stem Cells (Grant Agency of the Czech Republic)

- P301-11-1568 Cellular Aspects of Transplantation Tolerance (Grant Agency of the Czech Republic)

- Participation in projects funded by the Charles University Grant Agency

Are you interested in this expertise?

Please contact CPPT UK



Phone: +420 224 491 255

Experts and their department

RNDr. Magdaléna Krulová, Ph.D.

Departement of Cell Biology

Poslední změna: 11. říjen 2019 18:41 
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Centrum pro přenos poznatků a technologií, Univerzita Karlova



Tel.: +420 224 491 255

Adresa kanceláře:

Petrská 1180/3

110 00 Praha 1

Korespondenční adresa:

Ovocný trh 560/5

116 36 Praha 1

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