Department of Neuroscience












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            # Neurosciences

            # Regenerative medicine
            # Alzheimer's chicken, Huntington's disease
            # Fluorescence microscopy

            # EVOS






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            * Offer
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            - Meaurement of ion concentrations and the extracellular volume and tortuosity in situ and
            ion-selective microelectrodes
            - Measurements of biopotentials in the living tissue

            - Fluorescence microscopy of cell cultures and tissue samples
            - Image analysis including 3D morphometry






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            * Know-how & Technologies
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            - Our research focus is aimed at the changes of the extracellular space diffusion paramete
            (volume) transmission and neuron-glia interaction during physiological and pathological st
            - Furthermore we study stem cells and biomaterials in regenerative medicine.

            - We use various animal models of pathological states, e. g. models of global and focal is
            Alzheimer’s disease, Huntington’s disease, tumors, epilepsy, developmental disorders, agin
            spinal cord injury.






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            * Team Members

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            - Prof. Nathalie Rouach, CIRB, College de France, DR2 Inserm, Paris, France
            - Prof. Brigitte Onteniente, INSERM UMR 861, 91030 Evry cedex, France

            - Prof. Meenou Jhanwar-Uniyal, New York Medical College, New York, USA. Mutual grant from 
            II LH12024






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            * Key Research Equipment
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            The department is equiped with high technicaly advanced electrophysiological setups allowi
            of various biopotencials, extracellular ion concentrations and the extracellular space dif
            by a unique real-time iontophoretic method. It posses also several fluorescent microscopes

            evaluation of samples and image analysis, including a new digital inverted fluorescence mi





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            * Selected Publications
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            - Forostyak S, Homola A, Turnovcova K, Svitil P, Jendelova P, Sykova E. (2014) Intrathecal

            Mesenchymal Stromal Cells Protects the Structure of Altered Perineuronal Nets min SOD1 Rat
            Course of ALS. Stem Cells. 32(12):3163–72
            - Vargova L, Sykova E. (2014) Astrocytes and extracellular matrix in extrasynaptic volume 

            Philos Trans R Soc Lond B Biol Sci. 369(1654):20130608
            - Morawski M, Filippov M, Tzinia A, Tsilibary E, Vargova L. (2014) ECM in brain aging and 
            Brain Res. 214:207–27

            - Anderova M, Vorisek I, Pivonkova H, Benesova J, Vargova L, Cicanic M, Chvatal A, Sykova 
            death/proliferation and alterations in glial morphology contribute to changes in diffusivi
            hippocampus after hypoxia-ischemia. J. Cereb. Blood Flow Metab. 31(3):894–907

            - Pannasch U,. Vargova L, Reingruber J, Ezan P, Holcman D, Giaume C, Sykova E, Rouach N.: 
            networks scale synaptic activity and plasticity. Proc Natl Acad Sci U S A. 108(20):8467–72
            - Bekku Y, Vargova L, Goto Y, Vorisek I, Dmytrenko L, Narasaki M, Ohtsuka A, Fasler R, Nin

            E, Oohashi T: (2010) Bral-1: its role in diffusion barrier formation and conduction veloci





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            * Are you interested in this expertise?
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            Please contact CPPT UK

            Web: www.cppt.cuni.cz/ [ URL "https://cppt.cuni.cz/"]
            Mail: transfer@cuni.cz
            Phone: +420 224 491 255






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            * Experts and their Department

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            Assoc. Prof. Lýdia Vargová, M.D., Ph.D.
            Department of Neuroscience

            Web: https://www.lf2.cuni.cz/ustav-neuroved-2-lf-uk [ URL "https://www.lf2.cuni.cz/ustav-n





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            * Klíčová slova
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            # Neurovědy

            # Regenerativní medicína
            # Alzheimerova chroba, Huntingtonova choroba
            # Flurorescenční mikroskopie

            # EVOS