Clinical Physiology Unit ****************************************************************************************** * ****************************************************************************************** ****************************************************************************************** * Offer ****************************************************************************************** - Cooperation with partners on development and optimization of new protocols for advanced phenotyping mainly in the fields of experimental diabetology, endocrinology and nutrition - Using well established tests suited for customers‘ research needs (see „KNOW-HOW & TECHN section). Unit is equipped with qualified staff and all the equipment needed for providing physiology studies - Expertise in the area of human metabolism, diabetes, endocrinology and nutrition - Clinical trials conduct, patients/volunteers recruitment - Cooperation with research groups and companies in this field ****************************************************************************************** * Know-how & technologies ****************************************************************************************** - Insulin sensitivity and secretion measures (clamp studies, fast sampling IVGTT, glycaemi - Functional endocrinology testing - Tissue microdialysis - Indirect calorimetry, ergometry, physical exercise testing - Tissue biopsies and preparations - Arterio-venous balance studies ****************************************************************************************** * Research area & excelence ****************************************************************************************** - Clinical Physiology Unit (CPU) offers scientific solutions in basic research as well as involving human subjects. - We aim to develop and provide protocols for advanced metabolic phenotyping mainly in the experimental diabetology, endocrinology and nutrition. ****************************************************************************************** * Key research equipment ****************************************************************************************** - The unit operates on in-patient as well as out-patient basis. - CPU is equipped with three monitored beds and all the equipment and staff needed for pro physiology studies. - The unit has been accredited by Joint Comission Int. - CPU is equipped with indirect calorimeter and ergometer (Cosmed, Quark RMR), laminar flo and basic laboratory equipment. ****************************************************************************************** * Achievements ****************************************************************************************** Apomorphin test, high MUFA diet, BCAA and whey secretion tests, methionine test, exercise functional electrical stimulation. Vegan vs omnivore experimental model. ****************************************************************************************** * Partnerships & collaborations ****************************************************************************************** - Department for study on Diabetes and Obesity and Department of Hygiene, Third Faculty of Charles University - Deptment of Anaesthesia and Intensive Care Medicine - Kralovske Vinohrady University Hospital - Institute of Physiology of Academy of Science - Institute of Clinical and Experimental Medicine ****************************************************************************************** * Important publications ****************************************************************************************** - Altannavch TS, Roubalová K, Kucera P, Andel M.: Effect of high glucose concentrations on ELAM-1, VCAM-1 and ICAM-1 in HUVEC with and without cytokine activation. Physiol. Res. 200 IF = 1.6. 58 times cited. - Brunerova L, Smejkalova V, Potockova J, Andel M.: A comparison of the influence of a hig enriched in monounsaturated fatty acids and conventional diet on weight loss and metabolic obese non-diabetic and Type 2 diabetic patients. Diabet. Med. 2007;24(5):533– 540. 18 time 3.05. - Horácek J, Kuzmiaková M, Höschl C, And?l M, Bahbonh R.: The relationship between central activity and insulin sensitivity in healthy volunteers. Psychoneuroendocrinology 1999;24(8 times cited. IF = 4.94. - Syrovatka P, Kraml P, Potockova J, Fialova L, Vejrazka M, Crkovska J, Andel M.: Relation Increased Body Iron Stores, Oxidative Stress and Insulin Resistance in Healthy Men. Ann. N 2009;54(4):268–274. 25 times cited. IF = 2.461. - Gojda J, Jirka A, Strenkova J, Jarkovsky J, Tesinsky P.: PP180-SUN 20 Years of Home Pare Registry in the Czech Republic. Clin. Nutr. 2013;32:S90. - Tuma P, Gojda J.: Rapid determination of branched chain amino acids in human blood plasm assisted capillary electrophoresis with contactless conductivity detection. Electrophoresi doi:10.1002/elps.201400585. IF = 3.028. - Páv M, Hollý M, Cendelínová M, Gojda J, Polák J.: SOMA Score, cardiovascular risk screen psychiatric patients. Eur. Psychiatry 2016;33:S284–S285. - Jiroutková K, Krajčová A, Ziak J, Fric M, Waldauf P, Džupa V, Gojda J, Němcova-Fürstová Elkalaf M, Trnka J, Duška F.: Mitochondrial function in skeletal muscle of patients with p critical illness and ICU-acquired weakness. Crit. Care 2015;19(1). doi:10.1186/ s13054-015 7.44. - Gojda J, Rossmeislová L, Straková R, Tůmová J, Elkalaf M, Jaček M, Tůma P, Potočková J, Waldauf P, Trnka J, Štich V, Anděl M.: Chronic dietary exposure to branched chain amino ac glucose disposal in vegans but not in omnivores. Eur. J. Clin. Nutr. 2017. doi:10.1038/ejc 2.935. - Gojda J, Straková R, Plíhalová A, Tuma P, Potočková J, Polák J, Anděl M.: Increased Incr Not Insulin Response after Oral versus Intravenous Branched Chain Amino Acids. Ann. Nutr. 2017;70(4):293–302. IF = 2.461. ****************************************************************************************** * Are you interested in this expertise? ****************************************************************************************** Please contact CPPT UK Web: www.cppt.cuni.cz/ [ URL "https://cppt.cuni.cz/"] Mail: transfer@cuni.cz Phone: +420 224 491 255 ****************************************************************************************** * Experts and their department ****************************************************************************************** Jan Gojda, M.D., Ph.D. Centre for Research on Diabetes, Metabolism and Nutrition Department of Internal Medicine Web: https://www.lf3.cuni.cz/3LFEN-1.html [ URL "https://www.lf3.cuni.cz/3LFEN-1.html"]