Kostrouch Lab












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            "We study structure and function of cells in their normal state and in pathology – integra

            pathology. "





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            * Offer
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            - Detection and Research of hormonally active substances in the diet and in the environmen
            - Preparation of artificial proteins with special properties
            - C. elegans – genetics, genomics, genome editing






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            * Expertise

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            - Evolutionarily preserved mechanisms of regulation of gene expression
            - Development of systems for the production of artificial proteins

            - Bioinformatics and molecular biology of cancer
            - Research of hormonally active substances in food and the environment
            - Model systems of invertebrates

            - Molecular biology, genomics, genome editing





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            * Research Areas
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            The Laboratory of Molecular Pathology focuses primarily on the possible involvement of nuc

            cancers and other metabolic diseases. The research strategy is centered on nuclear recepto
            that are likely to be closely related to Deuterostome ancestors. The laboratory also studi
            of metabolism and development in flatworms and in Caenorhabditis elegans and searches for 

            in mammalian cell lines and in human cancers.
            In our working hypothesis Deuterostomes are a sister group to Diploblasts. Modern species 
            parallel from an evolutionary time point in the Precambrian era. Protostomes evolved more 

            laterally. We view cancers as tissues acquiring archetypical cellular behavior. We search 
            regulatory roles of nuclear receptors in this archetypical behavior of cells with the aim 
            the understanding of the role of nuclear receptors in cancers.






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            * Publications

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            - Novotny JP, Chughtai AA, Kostrouchova M, Kostrouchova V, Kostrouch D, Kassak F, Kana R, 
            B, Kostrouchova M, and Kostrouch Z. 2017. Trichoplax adhaerens reveals a network of nuclea

            sensitive to 9-cis-retinoic acid at the base of metazoan evolution. PeerJ 5:e3789. 10.7717
            - Kostrouchova M, Kostrouch D, Chughtai AA, Kassak F, Novotny JP, Kostrouchova V, Benda A,
            Saudek V, Kostrouchova M, and Kostrouch Z. 2017. The nematode homologue of Mediator comple

            F28F8.5, is a critical regulator of C. elegans development. PeerJ 5:e3390. 10.7717/peerj.3
            - Chughtai AA, Kassak F, Kostrouchova M, Novotny JP, Krause MW, Saudek V, Kostrouch Z, and
            M. 2015. Perilipin- related protein regulates lipid metabolism in C. elegans. PeerJ 3:e121

            peerj.1213
            - Kostrouchova M, and Kostrouch Z. 2015. Nuclear receptors in nematode development: Natura
            made by a phylum. Biochim Biophys Acta 1849:224-237. 10.1016/j. bbagrm.2014.06.016

            - Kostrouch D, Kostrouchova M, Yilma P, Chughtai AA, Novotny JP, Novak P, Kostrouchova V, 
            M, and Kostrouch Z. 2014. SKIP and BIR-1/Survivin have potential to integrate proteome sta
            expression. J Proteomics 110:93-106. 10.1016/j.jprot.2014.07.023






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            * Are you interested in this expertise?

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            Please contact CPPT UK
            Web: www.cppt.cuni.cz/ [ URL "https://cppt.cuni.cz/"]

            Mail: transfer@cuni.cz
            Phone: +420 224 491 255






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            * Experts and their department
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            Zdeněk Kostrouch, M.d., Csc.
            Biotechnology and Biomedicine Center of the Academy of Sciences and Charles University in 
            Web: https://www.biocev.eu/en [ URL "https://www.biocev.eu/en"]