Laboratory of Neurodegenerative Disorders












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            * Offer
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            - Tests of effects of chemical substances including pharmaceuticals on neural function

            - Design of the experimental protocol
            - Motor and behavioural tests in laboratory mice

            - Analysis and statistical processing of the data
            - Application of stem cells and chemical substances directly into mouse brain






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            * Expertise
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            - Laboratory of neurodegenerative disorders is focused on investigation of cerebellar dege
            - Functional impacts of cerebellar damage on motor function as well as cognitive and emoti
            are studied in several mouse models of hereditary cerebellar degeneration.

            - The next research area is investigation of experimental neurotransplantation and regener
            neurodegenerative diseases.
            - This research includes in vitro and in vivo studies of the effect of trophic and morphog

            proliferation and development of neural stem cells.





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            * Members
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            - Assoc. Prof. Jan CendelÍn, M.D., Ph.D. – Research Group Leader

            - Jiřina Babická, M.Sc.
            - Filip Tichánek, M.Sc.
            - Jan Tůma, Ph.D., MSc.

            - Assoc. Prof. František Vožeh, M.D., Ph.D.





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            * Cost action membership
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            - BM0901 – European systems genetics network for the study of complex genetic human diseas

            genetic reference populations (SYSGENET)
            - BM1001 – Brain Extracellular Matrix in Health and Disease (ECMNet)






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            * Selected Publications
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            - Babuska V, Houdek Z, Tuma J, Purkartova Z, Tumova J, Kralickova M, Vozeh F, Cendelin J.:
            of Embryonic Cerebellar Grafts Improves Gait Parameters in Ataxic Lurcher Mice. Cerebellum
            - Kolinko Y., Krakorova K., Cendelin J., Tonar Z., Kralickova M.: Microcirculation of the 

            morphological assessment in degenerative diseases and restoration processes. Rev Neurosci 
            - Cendelin J., Tuma J., Korelusova I., Vozeh F.: The effect of genetic background on behav
            manifestation of Grid2Lc mutation. Behav Brain Res 271: 218–227, 2014

            - Cendelin J.: From mice to men: lessons from mutant ataxic mice. Cerebellum & Ataxias 1: 
            - Purkartova Z., Tuma J., Pesta M., Kulda V., Hajkova L., Sebesta O., Vozeh F., Cendelin J
            analysis of embryonic cerebellar grafts in SCA2 mice. Neurosci Lett 558: 154–158, 2014

            - Cedikova M, Houdek Z, Babuska V, Kulda V, Vozeh F, Zech N., et al.: Fate of two types of
            in wild type and cerebellar mutant mice. J Appl Biomed 12: 17–23, 2014






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            * Are you interested in this expertise?
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            Please contact CPPT UK
            Web: www.cppt.cuni.cz/ [ URL "https://cppt.cuni.cz/"]
            Mail: transfer@cuni.cz

            Phone: +420 224 491 255





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            * Experts and their Department
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            Assoc. Prof. Jan Cendelín, M.D., Ph.D.

            Institute of Pathological Physiology
            Web: www.biomedic-plzen.cz [ URL "http://www.biomedic-plzen.cz"]