Laboratory of Experimental Neurophysiology












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            "Our goal is to understand mechanisms of memory processing on the level of brain neural ne






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            * Offer

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            - Extracellular single neuron activity, chronically implanted microelectrodes

            - EEG recorded through superficial or deep electrodes
            - Behavior in cognitive tasks under parallel registration of single neuron activity
            - Memory tests in animal models (rat, mouse)

            - Relation between EEG, single unit activity and behavior (sleep, locomotion, cognitive ta
            - EEG analysis
            - Analysis of memory tests






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            * Expertise

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            - The lab’s concept is to systematically explore properties of memory processing across ne
            hippocampus and connected cortical areas

            - We mainly record electric activity from populations of place cells in laboratory rats an
            neural information in high temporal resolution
            - This enables to study detailed kinetics of memory processing and to relate it with local

            oscillations and behavior





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            * Research Area & Excellence
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            We focus on hippocampal circuits and their interactions with neocortical areas. Hippocampa

            found crucial for declarative memory in humans and certain types of cognitive abilities in
            for orientation and spatial memory.
            Because we can read the information code in hippocampal pyramidal cells relatively well, t

            provides a fascinating field offering a direct insight into mechanisms of how brain repres
            world and how this information is later recalled.






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            * Members
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            - Karel Ježek, M.D., Ph.D. – Research Group Leader
            - Karel Blahna, M.D.
            - Helena Geciová

            - Štěpán Kápl, M.Sc.
            - Michael Mareš
            - André Oliveira, M.D.

            - Zuzana Petránková, Ph.D., M.Sc.
            - M.C.P. Stephanie Lissette Proskauer-Pe?a
            - Lenka Sýkorová, M.Sc.

            - Pavel Šnejdar, B.Sc.
            - František Zitrický, M.D.






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            * Selected Publications
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            - Alme CB, Miao C, Jezek K, Treves A, Moser E, Moser MB. Place cells in the hippocampus: E
            eleven rooms. PNAS, 2014. 111 (52): 18428–35
            - Rose T, Schoenenberger P, Jezek K, Oertner TG. Developmental Refinement of Vesicle Cycli

            Collateral Synapses. Neuron, 2013. 77 (6): 1109–1121
            - Jezek K, Henriksen EJ, Treves A, Moser E, Moser MB. Theta-paced flickering between place
            hippocampus. Nature, 2011. Sep 28; 478 (7368): 246–9

            - Stella F, Cerasti E, Bailu Si, Jezek K, Treves A. Self-organization of multiple spatial 
            memories in the hippocampus. Neurosci & Biobehavior Rev. 2012. 36 (7): 1609–25
            - Jezek K, Lee B, Kelemen E, McCarthy K, McEwen BS, Fenton AA. Stress-induced Out-of-Conte

            Memory. PLoS Biology, 2010. 8 (12): e1000570-13





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            * Are you interested in this expertise?
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            Please contact CPPT UK

            Web: www.cppt.cuni.cz/ [ URL "https://cppt.cuni.cz/"]
            Mail: transfer@cuni.cz
            Phone: +420 224 491 255






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            * Experts and their department

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            Karel Ježek, M.D., Ph.D.
            Biomedical Center

            Web: http://www.biomedic-plzen.cz/cz [ URL "http://www.biomedic-plzen.cz/cz"]