Laboratory of Experimental Intensive Care Medicine












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            * Offer
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            - Independent testing of the efficacy and safety of novel candidate molecules

            - Independent evaluation of the efficacy and safety of novel extracorporeal methods of org
            replacement

            - Rapid and comprehensive reporting of high quality proof–of-concept results, including st
            analyses and data interpretation
            - Advice prior to initiation of a study and experimental design helping

            - Consultation in the development of models
            - Confidential data that are the sole property of the client International reputation with
            years of experience in experimental research

            - Long-term policy of bilateral cooperation





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            * Exeprtise
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            The mission is the study of the mechanisms of acute (multi)organ dysfunction and injury, i

            testing of emerging treatment targets and molecules, evaluation of the efficacy, safety an
            novel methods of organ replacement. The strategic areas include:


            - Dynamic Modeling of Acute Illness
            - Fundamental cell and molecular biological studies of the basis for organ dysfunction
            - Organ protection and regeneration; Extracorporeal organ support and replacement

            - New Biological Markers.

            The multi-disciplinary team comprises basic science and clinical researchers, bioengineeri

            biomaterials experts, and experts in complex systems modeling.





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            * Exeprtise
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            The mission is the study of the mechanisms of acute (multi)organ dysfunction and injury, i

            and testing of emerging treatment targets and molecules, evaluation of the efficacy, safet
            of novel methods of organ replacement. The strategic areas include:


            - Dynamic Modeling of Acute Illness
            - Fundamental cell and molecular biological studies of the basis for organ dysfunction
            - Organ protection and regeneration; Extracorporeal organ support and replacement

            - New Biological Markers.

            The multi-disciplinary team comprises basic science and clinical researchers, bioengineeri

            biomaterials experts, and experts in complex systems modeling.





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            * Members
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            - Prof. Martin Matějovič, M.D., Ph.D. – Research Group Leader

            - Assoc. Prof. Jan Beneš, M.D., Ph.D.
            - Lenka Karlíková
            - Thomas Karvunidis, M.D.

            - Jaroslav Raděj, M.D.
            - Jan Horák, M.D.
            - Simona Táborská, M.Sc.

            - Eva Němcová, M.Sc.
            - Adéla Turhobrová, B.Sc.






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            * Selected Publications
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            - Searching for mechanisms that matter in early septic acute kidney injury: an experimenta
            Care, 2011, vol. 15, no. 5, p. R256
            - High versus standard-volume haemofiltration in hyperdynamic porcine peritonitis: effects

            haemodynamics? Intensive Care Med, 2009, vol. 35, p. 371–380
            - Coupled plasma filtration adsorption in experimental peritonitis- induced septic shock. 
            31, no. 5, p. 473–480

            - Regional cooling of the extracorporeal blood circuit: a novel anticoagulation approach f
            replacement therapy? Intensive Care Med, 2009, vol. 35, no. 2, p. 364–370
            - Renal hemodynamic, microcirculatory, metabolic and histopatological responses to periton

            septic shock in pigs. Crit Care, 2008, vol. 12, no. 6, p. R164
            - Selective inducible nitric oxide synthase inhibition during long-term hyperdynamic porci
            Shock, 2004, vol. 21, no. 5, p. 458–465






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            * Are you interested in this expertise?

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            Please contact CPPT UK
            Web: www.cppt.cuni.cz/ [ URL "https://cppt.cuni.cz/"]

            Mail: transfer@cuni.cz
            Phone: +420 224 491 255






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            * Experts and their department
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            Prof. Martin Matějovič, M.D., Ph.D.
            University Hospital Pilsen – I. Medical Department
            Web: http://www.lfp.cuni.cz/index.php [ URL "http://www.lfp.cuni.cz/index.php"]