Laboratory of Cancer Treatment and Tissue Regeneration ****************************************************************************************** * ****************************************************************************************** ****************************************************************************************** * Offer ****************************************************************************************** - Preparation of experimental large animals models including surgical and anesthesiologica - Follow-up of animals by imaging, biochemical and immunological methods ****************************************************************************************** * Expertise ****************************************************************************************** - Long-term aims - Regeneration of liver parenchyma and liver surgery - Portal micro- and macrocirculation - Reconstruction of portal system - Surgical and oncological treatment of malignancies - Immune system behaviour during progression of tumour disease ****************************************************************************************** * Research Area & Excellence ****************************************************************************************** Our laboratory is concerned on study of regeneration of parenchymal organs in a relation t extensive surgical procedures. Our goal is to experimentally verify all possibilities that the treatment of patients with cancers, especially liver malignancies. We are checking the stimulated regeneration of the future liver remnant damaged for example by oncologic exper in large animals (established are experimental model of steatohepatitis associated with ch of toxic alcoholic liver disease, model of biliary cirrhosis etc.) We also develop special software models and advanced imaging analysis to predict regenerat the liver parenchyma and diagnose focal and diffuse liver diseases. There is also included imaging of a portal system microcirculation as well. Finally we use to spread our clinical treatment possibilities. We closely cooperate with the Labs of Phar Tumor Biology and Quantitative Histology and we try to transfer their research results to requirements and applications. Our team is fully instrumentally equipped to perform experiments in large animals. We also team of experts (including surgeons, anaesthesiologists, radiologists, biomechanics or exp theoretical and laboratory fields) available to perform broad spectrum of surgical procedures. This team participates every year in preparing of the Summer School of Experimental Surger by our medical school. ****************************************************************************************** * Members ****************************************************************************************** - Assoc. Prof. Václav Liška, M.D., Ph.D. – Research Group Leader - Kristýna Bajcurová, M.D. - Jan Brůha, M.D. - Ondřej Brzoň, B.Sc. - Lada Eberlová, M.D., Ph.D. - Ondřej Fiala, M.D., Ph.D. - Assoc. Prof. Luboš Holubec, M.D., MBA, Ph.D. - Petr Hošek, Ph.D., M.Sc. - Miroslav Jiřík, M.Sc. - Marie Karlíková, Ph.D., M.Sc. - Eva Korčáková, M.D. - Prof. Boris Kreuzberg, M.D., Ph.D. - Patrik Mik, M.Sc. - Hynek Mírka, M.D., Ph.D. - Vladislava Mlejnková Dvořáková, M.Sc. - Richard Pálek, M.D. - Jáchym Rosendorf, M.D. - Martin Skála, M.D. - Miroslava Svobodová, Ph.D., MSc. - Prof. Vladislav Třeška, M.D., Ph.D. - Ondřej Vyčítal, M.D., Ph.D. ****************************************************************************************** * Selected Publications ****************************************************************************************** - Svoboda M., Slyšková J., Schneiderová M., Makovický P., Bielik L., Levý M., Lipská L., H Z., Protivanková M., Vyčítal O., Liška V., Schwarzová L., Vodičková L., Vodička P.: HOTAIR RNA is a negative prognostic facotr not only in primary tumors, but also in the blood of c patients. Carcinogenesis, 2014, 35: 1510–1515 - Flanagan L., Schmid J., Ebert M., Souček P., Kunická T., Liška V., Brůha J., Neary P., D Tommasino M., Jenab M., Prehn J.H., Hughes D.J.: Fusobacterium nucleatum associates with s colorectal neoplasia development, colorectal cancer and disease outcome. Eur J Clin Microb 2014, 33: 1381–1390 - Slyšková J., Cordero F., Pardini B., Kořenková V., Vymetálková V., Bielik L., Vodičková Liška V., Matějka V., Levý M., Buchler T., Kubišta M., Naccarati A., Vodička P.: Post-trea of suboptimal DNA repair capacity and gene expression levels in colorectal cancer patients 2014, electronic publication - Třeška V., Liška V., Fichtl J., Lysák D., Mírka H., Brůha J., Duras P., Třešková I., Náh V., Topolčan O.: Portal vein embolization with application of haematopoietic stem cells in primarily or non-resectable colorectal liver metastases. Anticancer Res., 2014, 34: 7279–7 - Slyšková J., Korenková V., Collins A.R., Procházka P., Vodičková L., Švec J., Lipská L., Schneiderová M., Liška V., Holubec L., Kumar R., Souček P., Naccarati, Vodička P.: Functio epigenetic aspects of base and nukleotide excision repair in colorectal carcinoma. Clin Ca 18: 5878–5887 - Liška V., Třeška V., Mírka H., Beneš J., Vyčítal O., Brůha J., Pitule P., Skalický T., S Chlumská A., Racek J., Trefil L., Fínek J., Holubec L.: Immediately Preoperative use of Bi Does not Influence Liver Regeneration after Large Resection - Porcine Experimental Model w Antibody against Epidermal Growth Factor. In Vivo, 2012, 26: 683–691 - Kochová P., Kuncová J., Švíglerová J., Cimrman R., Miklíková M., Liška V., and Tonar Z.: of vascular smooth muscle, elastin and collagen on the passive mechanics of porcine caroti Physiol. Meas., 2012, 33: 1335–1351 ****************************************************************************************** * Are you interested in this expertise? ****************************************************************************************** Please contact CPPT UK Web: www.cppt.cuni.cz/ [ URL "https://cppt.cuni.cz/"] Mail: transfer@cuni.cz Phone: +420 224 491 255 ****************************************************************************************** * Experts and their department ****************************************************************************************** Assoc. Prof. Václav Liška, M.D., Ph.D. Biomedical Center Web: http://www.biomedic-plzen.cz/cz [ URL "http://www.biomedic-plzen.cz/cz"]