In Vivo Evaluation of Antituberculotic Activity












            ******************************************************************************************

            *
            ******************************************************************************************
            "In vivo evaluation of antituberculotic activity of agents with efficacy against Mycobacte

            we developed and verified, is now available for you."





            ******************************************************************************************

            * Offer
            ******************************************************************************************

            - We offer our newly established method for commercial testing of samples and processing o
            report which involves: number of M. tuberculosis CFU in lungs and spleen in LMWC-treated m
            control mice with strandard treatment and without treatment

            - We would like to offer you the cooperation in form of contract research secured by MTA a
            - We are able to prepare an offer exclusively for you and for your needs, according to you
            requirements






            ******************************************************************************************
            * Expertise

            ******************************************************************************************
            - Our group currently pursues research in potential antituberculosis agents based on subst
            heterocycles with extraordinary antituberculotic activity

            - Agents of this group are considerably active (up to 0.03 ?mol. l–1) in vitro, indicate v
            in vitro and in vivo, genotoxicity and cytotoxicity
            - The Group has all the resources necessary for reliable research, including monitoring of

            toxicity in vivo with all necessary permissions for these activities (Reg. No. 53093/2013-
            No. 246/1992 Coll.)
            - The antitubercular effect of the LMWC is studied after one, two or three months of the a

            On the last day of the treatment period the number of M. tuberculosis colony forming units
            and spleen are evaluated. The antituberculosis effect of studied LMWC is compared with unt
            and control treated with standard antituberculosis drugs (isoniazid, rifampicin or pyrazin

            combination
            - The experimental animals are BALB/c mice






            ******************************************************************************************
            * Are you interested in this expertise?
            ******************************************************************************************

            Please contact CPPT UK
            Web: www.cppt.cuni.cz/ [ URL "https://cppt.cuni.cz/"]
            Mail: transfer@cuni.cz

            Phone: +420 224 491 255





            ******************************************************************************************

            * Experts and their department
            ******************************************************************************************
            Prof. PharmDr. Alexandr Hrabálek, CSc.

            Department of Organic And Bioorganic Chemistry