Group od Coordination and Bioinorganic Chemistry ****************************************************************************************** * ****************************************************************************************** "We are looking for cooperation in the fields of molecular imaging (Mri, Pet, sPeCt, and o radiotherapy (theranostics) and other applications of metal complexes in biomedical scienc medicine)." ****************************************************************************************** * Offer ****************************************************************************************** - We offer our expertise within a diverse range of issues related to design, synthesis, ch and medicinal application of chelators and their metal complexes as well as some of their conjugates with bis(phosphonate) group for bone targeting). - We are able to design and synthesize bifunctional macrocyclic ligands for a particular a with advantage, we employ our long-term experience with organophosphorus chemistry. ****************************************************************************************** * Know-how & Technologies ****************************************************************************************** - Synthesis and characterization of new macrocyclic ligands and their complexes - Contrast agents for Magnetic Resonance Imaging (MRI) - Carriers of metal radioisotopes for radiodiagnostics (SPECT, PET) - Radiopharmaceuticals for imaging or therapy of tumors and metastases - We have a unique expertise in determination of stability constants of metal complexes ****************************************************************************************** * Main Capabilities ****************************************************************************************** Coordination chemistry, chemistry of macrocyclic ligands, organophosphorus chemistry, prob imaging or therapy, potentiometry, NMR, MS, X-ray, optical methods. ****************************************************************************************** * Partners and Collaborations ****************************************************************************************** *========================================================================================= * Academic Partners *========================================================================================= - Cooperation with many academic research groups in the Czech Republic as well as in Europ collaborative projects (Munich, Mainz, Dresden, Nantes, Torino, Oxford, Hull) - Several complexes have been advanced into clinics as experimental radiopharmaceuticals, and therapy (imaging/treatment of bone metastases, tenths of successfully treated patients - Important cooperation with MRI laboratory of Institute for Clinical and Experimental Med - Participation in the international projects – 6th framework programme, COST projects (fr participation starting in 1999), bilateral cooperation *========================================================================================= * Public and Private Sector *========================================================================================= - RadioMedic, s.r.o. - Interpharma Praha a.s. - Quinta, s.r.o. ****************************************************************************************** * Main Recent Projects ****************************************************************************************** - Grant Agency of the Czech Republic, 16-03156S „Self-assembly polymeric nanostructures as resonance – ultrasound contrast agents for imaging“ - Grant Agency of the Czech Republic, 17-13721S “Copper radioisotopes and new theranostics - COST CA15209 – “European network on NMR relaxometry (EURELAX)“ - Ministry of Education of the Czech Republic, Inter-Excellence LTC17067 “Application of N diff usion measurements for determination of dynamics of complex molecular systems” ****************************************************************************************** * Achievements ****************************************************************************************** In the last 10 years, more than 80 papers in international journals. - Book chapter “Synthesis and Characterization of Ligands and their Gadolinium(III) Comple Chemistry of Contrast Agents in Medical Magnetic Resonance Imaging“ (A. E. Merbach, L. Hel John Wiley & Sons 2013 (ISBN978-1-119-99176-2) ****************************************************************************************** * Patents ****************************************************************************************** - T. David, P. Hermann, V. Kubíček: „Cyclam based compounds, their conjugates, co-ordinati pharmaceutical composition containing thereof, method of preparation and use thereof“ PCT (2017) - I. Lukeš, P. Hermann: „Novel Chelating Agents of Tetraazacyclododecanemethyl- phosphonic Derivatives and Their Conjugates, Their Synthesis and Use as Diagnostic and Therapeutic Ag Appl. WO03008394 (2003) "Our mission is the development of new medicinal probes for improved medical imaging techn metal radioisotope carriers for imaging or radiotherapy." ****************************************************************************************** * Are you interested in this expertisa? ****************************************************************************************** Please contact CPPT UK Web: www.cppt.cuni.cz/ [ URL "https://cppt.cuni.cz/"] Mail: transfer@cuni.cz Tel.: +420 224 491 255 ****************************************************************************************** * Experts and their department ****************************************************************************************** Prof. RNDr. Petr Hermann, Dr. Department of Inorganic Chemistry Web: http://web.natur.cuni.cz/anorchem/19 [ URL "http://web.natur.cuni.cz/anorchem/19"]